Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

Author(s): Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham FahmyPages 50-59 (10) Abstract: Corticotropin-releasing factor (CRF) is a neurohormone that plays a crucial role in integrating the body’s overall response to stress. It appears necessary and sufficient for the organism to mount functional, physiological...

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Overview of Binding Free Energy Calculation Techniques for Elucidation of Biological Processes and for Drug Discovery

Author(s): Takeshi Ashida and Takeshi KikuchiPages 248-253 (6) Abstract: The elucidation of the interactions between a protein and a ligand or proteins is a key issue for understanding of functional processes of various proteins, enzymes and receptors in biological organisms, system biology and drug design. One of the most important matters in these problems is the...

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Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

Author(s): Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju SunPages 383-390 (8) Abstract: Lycium barbarum polysaccharide (LBP) has traditionally been used in Chinese medicine as a chief ingredient of Lycium barbarum(wolf berry/goji berry) for the treatment of various diseases with the symptoms...

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Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

Author(s): Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella PaolinoPages 391-399 (9) Abstract: Therapeutic guidelines indicate prostacyclin as the first line of treatment in inflammation...

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